abstract：BACKGROUND:Delivering solutes to a particular region of the brain is currently achieved by iontophoresis for very small volumes and by diffusion from a microdialysis probe for larger volumes. There is a need to deliver solutes to particular areas with more control than is possible with existing methods. NEW METHOD:Ele...

journal_title：Journal of neuroscience methods

authors： Faraji AH,Jaquins-Gerstl AS,Valenta AC,Weber SG

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Supra-threshold galvanic vestibular stimulation (GVS) can be used to challenge the balance control system by disrupting vestibular inputs. The goal of this study was to propose an objective method to assess variability across subjects in the minimum safe GVS level that causes maximum balance degradation. New...

journal_title：Journal of neuroscience methods

authors： Goel R,Rosenberg MJ,Cohen HS,Bloomberg JJ,Mulavara AP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Weak or low intensity transcranial stimulation of the brain, such as low field magnetic stimulation and electrical stimulation, can produce significant functional and therapeutic neuromodulatory effects. NEW METHOD:We have recently developed a portable wearable multifocal brain stimulator called transcrania...

journal_title：Journal of neuroscience methods

authors： Helekar SA,Convento S,Nguyen L,John BS,Patel A,Yau JM,Voss HU

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Application of functional Near InfraRed Spectroscopy (fNIRS) in neurology is still limited as a good optical coupling and optimized optode coverage of specific brain regions remains challenging, notably for prolonged monitoring. METHODS:We propose to evaluate a new procedure allowing accurate investigation ...

journal_title：Journal of neuroscience methods

authors： Machado A,Cai Z,Pellegrino G,Marcotte O,Vincent T,Lina JM,Kobayashi E,Grova C

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The sound fed to a loudspeaker may significantly differ from that reaching the ear of the listener. The transformation from one to the other consists of spectral distortions with strong dependence on the relative locations of the speaker and the listener as well as on the geometry of the environment. With th...

journal_title：Journal of neuroscience methods

authors： Kazakov A,Nelken I

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Electroencephalography (EEG) experiments often require several computers to ensure accurate stimulus presentation and data collection. However, this requirement can make it more difficult to perform such experiments in mobile settings within, or outside, the laboratory. NEW METHOD:Computer miniaturisation a...

journal_title：Journal of neuroscience methods

authors： Kuziek JWP,Redman EX,Splinter GD,Mathewson KE

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Athletes, military personnel and mobility-declined elderly people are prone to repetitive mild traumatic brain injury (rmTBI). The injury does not cause acute pathological changes, but leads to chronic neurodegeneration, long-term cognitive dysfunction and even chronic traumatic encephalopathy (CTE). Many ex...

journal_title：Journal of neuroscience methods

authors： Ge X,Yu J,Huang S,Yin Z,Han Z,Chen F,Wang Z,Zhang J,Lei P

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Preprocessed Event-related potential (ERP) data are usually organized in multi-way tensor, in which tensor decomposition serves as a powerful tool for data processing. Due to the limitation of computation burden for multi-way data and the low algorithm performance of stability and efficiency, multi-way ERP d...

journal_title：Journal of neuroscience methods

authors： Wang D,Zhu Y,Ristaniemi T,Cong F

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) is commonly used to infer hemodynamic changes in the brain after increased neural activity, measuring the blood oxygen level-dependent (BOLD) signal. An important challenge in the analyses of fMRI data is to develop methods that can accurately deconvolve the BOLD ...

journal_title：Journal of neuroscience methods

authors： Pang JC,Aquino KM,Robinson PA,Lacy TC,Schira MM

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Over the past decade, pattern decoding techniques have granted neuroscientists improved anatomical specificity in mapping neural representations associated with function and cognition. Dynamical patterns are of particular interest, as evidenced by the proliferation and success of frequency domain methods tha...

journal_title：Journal of neuroscience methods

authors： Singh MF,Braver TS,Ching S

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Putative treatments derived from in vivo stem cell transplant-derived dopamine (DA) in hemiparkinsonian rats have been assessed via DA-agonist-induced rotations involving imbalanced intra-hemispheric striatal DA receptor stimulation. However, such tests obscure the natural responses of grafts to sensory stim...

journal_title：Journal of neuroscience methods

authors： Bhupal PK,Anderson KA,Shall GP,Lynn JD,Hoolsema KS,Rossignol J,Dunbar GL,Sandstrom MI

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Demyelination is the end product of numerous pathological processes, and also is one of the main causes of neurological disability in Multiple sclerosis (MS). Research into the pathogenesis of MS is hampered by the conventional rodent models' inability to produce stable demyelination. NEW METHOD:Focal demye...

journal_title：Journal of neuroscience methods

authors： Luo Q,Ding L,Zhang N,Jiang Z,Gao C,Xue L,Peng B,Wang G

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:A reliable inference of networks from data is of key interest in the Neurosciences. Several methods have been suggested in the literature to reliably determine links in a network. To decide about the presence of links, these techniques rely on statistical inference, typically controlling the number of false ...

journal_title：Journal of neuroscience methods

authors： Cecchini G,Thiel M,Schelter B,Sommerlade L

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Stereotaxic procedures in rats are frequently used in neurological research. The commonly used rat brain stereotaxic atlases areThe Rat Brain in Stereotaxic Coordinates, the second most cited book in science, and Stereotaxic Atlas of Rat Brain (in Chinese) which based on Wistar rats of 290 g and SD rats of 2...

journal_title：Journal of neuroscience methods

authors： Yang P,Wang Z,Zhang Z,Liu D,Manolios EN,Chen C,Yan X,Zuo W,Chen N

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Artificial neural networks (ANNs) are one of the widely used classifiers in the brain-computer interface (BCI) systems-based on noninvasive electroencephalography (EEG) signals. Among the different ANN architectures, the most commonly applied for BCI classifiers is the multilayer perceptron (MLP). When appro...

journal_title：Journal of neuroscience methods

authors： Hettiarachchi IT,Babaei T,Nguyen T,Lim CP,Nahavandi S

更新日期：2018-07-15 00:00:00

abstract：BACKGROUND:Peripheral neuropathies affect approximately 20 million people in the United States and often stem from other chronic conditions, such as diabetes. In vitro methodologies to facilitate the understanding and treatment of these disorders often lack the cellular and functional complexity required to accurately ...

journal_title：Journal of neuroscience methods

authors： Anderson WA,Willenberg AR,Bosak AJ,Willenberg BJ,Lambert S

更新日期：2018-07-15 00:00:00

abstract：BACKGROUND:Mixed frequency and phase coding (FPC) can achieve the significant increase of the number of commands in steady-state visual evoked potential-based brain-computer interface (SSVEP-BCI). However, the inconsistent phases of the SSVEP over channels in a trial and the existence of non-contributing channels due t...

journal_title：Journal of neuroscience methods

authors： Morikawa N,Tanaka T,Islam MR

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:How experience and individuality shape action selection remains a major question in neuroscience. Visually-evoked escape behavior within Drosophila melanogaster provides a robust model to study these mechanisms within neural circuits but requires novel assays to circumvent limitations of current behavior ass...

journal_title：Journal of neuroscience methods

authors： Goodman DP,Eldredge A,von Reyn CR

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Synchronous detecting neuron spikes and dopamine (DA) activities in the non-human primate brain play an important role in understanding of Parkinson's disease (PD). At present, most experiments are carried out by combing of electrodes and commercial instruments, which are inconvenient, time-consuming and ine...

journal_title：Journal of neuroscience methods

authors： Xu S,Zhang Y,Zhang S,Xiao G,Wang M,Song Y,Gao F,Li Z,Zhuang P,Chan P,Tao G,Yue F,Cai X

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:The use of wearable technology is an emerging field of research in movement disorders. This paper introduces a clinical study to evaluate the feasibility, clinical correlation and reliability of using a system based in smartwatches to quantify tremor in essential tremor (ET) patients and check its acceptance...

journal_title：Journal of neuroscience methods

authors： López-Blanco R,Velasco MA,Méndez-Guerrero A,Romero JP,Del Castillo MD,Serrano JI,Benito-León J,Bermejo-Pareja F,Rocon E

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Magnetoencephalography (MEG) and Electroencephalography (EEG) are noninvasive techniques to study the electrophysiological activity of the human brain. Thus, they are well suited for real-time monitoring and analysis of neuronal activity. Real-time MEG/EEG data processing allows adjustment of the stimuli to ...

journal_title：Journal of neuroscience methods

authors： Esch L,Sun L,Klüber V,Lew S,Baumgarten D,Grant PE,Okada Y,Haueisen J,Hämäläinen MS,Dinh C

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia in the elderly population. Scientific research is very active in the challenge of designing automated approaches to achieve an early and certain diagnosis. Recently an international competition among AD predictors has been organi...

journal_title：Journal of neuroscience methods

authors： Nanni L,Lumini A,Zaffonato N

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:In the era of computer-assisted diagnostic tools for various brain diseases, Alzheimer's disease (AD) covers a large percentage of neuroimaging research, with the main scope being its use in daily practice. However, there has been no study attempting to simultaneously discriminate among Healthy Controls (HC)...

journal_title：Journal of neuroscience methods

authors： Dimitriadis SI,Liparas D,Tsolaki MN,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:We present our results in the International challenge for automated prediction of MCI from MRI data. We evaluate the performance of MRI-based neuromorphometrics features (nMF) in the classification of Healthy Controls (HC), Mild Cognitive Impairment (MCI), converters MCI (cMCI) and Alzheimer's Disease (AD) p...

journal_title：Journal of neuroscience methods

authors： Donnelly-Kehoe PA,Pascariello GO,Gómez JC,Alzheimers Disease Neuroimaging Initiative.

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:The accuracy of source reconstruction depends on the spatial configuration of the neural sources underlying encephalographic signals, the temporal distance of the source activity, the level and structure of noise in the recordings, and - of course - on the employed inverse method. This plenitude of factors r...

journal_title：Journal of neuroscience methods

authors： Kalogianni K,de Munck JC,Nolte G,Vardy AN,van der Helm FCT,Daffertshofer A

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Zebrafish larvae have a high potential as model system to replace rodents, especially in screening and drug discovery applications. However, an experimental setup to deliver mild electrical stimuli with simultaneous high throughput behavioural tracking has not yet been described. NEW METHOD:A new tool was d...

journal_title：Journal of neuroscience methods

authors： Steenbergen PJ

更新日期：2018-05-01 00:00:00

abstract：:An important factor in reducing variability in mouse test outcomes has been to develop assays that can be used for continuous automated home cage assessment. Our experience has shown that this has been most evidenced in long-term assessment of wheel-running activity in mice. Historically, wheel-running in mice and oth...

journal_title：Journal of neuroscience methods

authors： Bains RS,Wells S,Sillito RR,Armstrong JD,Cater HL,Banks G,Nolan PM

更新日期：2018-04-15 00:00:00

abstract：:There are many reasons why novel therapeutics fail in clinical trials but these failures are often attributed to lacking quality of preclinical data. These problems are not limited to any specific therapeutic area, academic or industrial research and are due in large part to several generic factors influencing researc...

journal_title：Journal of neuroscience methods

authors： Bespalov A,Steckler T

更新日期：2018-04-15 00:00:00

abstract：BACKGROUND:The detection of high-frequency oscillations (HFOs, ripples: 80-200 Hz, fast ripples: 250-500 Hz) is often based on considering ripples or fast ripples in isolation; overlapping ripples and fast ripples are excluded from further analysis. Here, we studied overlapping HFOs during spontaneous seizures in piloc...

journal_title：Journal of neuroscience methods

authors： Lévesque M,Wang S,Gotman J,Avoli M

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:We analyze the dynamics of rodent EEG amplitude in an experiment accompanied by video recordings. Brain activity of animals is commonly acquired together with a video of behavior, but recordings are rarely combined in analysis. The data acquired is most commonly analyzed separately. To our knowledge, no stud...

journal_title：Journal of neuroscience methods

authors： Jurica P,Struzik ZR,Li J,Horiuchi M,Hiroyama S,Takahara Y,Nishitomi K,Ogawa K,Cichocki A

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Fear conditioning (FC) in rodents is the most used animal model to investigate the neurobiology of posttraumatic stress disorder (PTSD). Although research using FC has generated a better understanding of fear memories, studies often rely on mild or moderate FC training and behavioral analysis generally focus...

journal_title：Journal of neuroscience methods

authors： Souza RR,Robertson NM,Pruitt DT,Noble L,Meyers EC,Gonzales PA,Bleker NP,Carey HL,Hays SA,Kilgard MP,McIntyre CK,Rennaker RL

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Statistical models that predict neuron spike occurrence from the earlier spiking activity of the whole recorded network are promising tools to reconstruct functional connectivity graphs. Some of the previously used methods are in the general statistical framework of the multivariate Hawkes processes. However...

journal_title：Journal of neuroscience methods

authors： Lambert RC,Tuleau-Malot C,Bessaih T,Rivoirard V,Bouret Y,Leresche N,Reynaud-Bouret P

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Over 90 years after its first recording, scalp electroencephalography (EEG) remains one of the most widely used techniques in human neuroscience research, in particular for the study of event-related potentials (ERPs). However, because of its low signal-to-noise ratio, extracting useful information from thes...

journal_title：Journal of neuroscience methods

authors： Lopes-Dos-Santos V,Rey HG,Navajas J,Quian Quiroga R

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:Image segmentation is often imperfect, particularly in complex image sets such z-stack micrographs of slice cultures and there is a need for sufficient details of parameters used in quantitative image analysis to allow independent repeatability and appraisal. NEW METHOD:For the first time, we have criticall...

journal_title：Journal of neuroscience methods

authors： Healy S,McMahon J,Owens P,Dockery P,FitzGerald U

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The misallocation of treatment-variance on the wrong component has been discussed in the context of temporal principal component analysis of event-related potentials. There is, until now, no rotation-method that can perfectly recover Wood and McCarthy's prototypes without making use of additional information...

journal_title：Journal of neuroscience methods

authors： Beauducel A

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The vestibular lesion (VL) is required to examine the physiological function of the vestibular system in animals. Toxic chemicals or electrical apparatus have been used for the VL, however, they are not ideal as they have low specificity, and can result in unintended damage, and systemic toxic effect. NEW M...

journal_title：Journal of neuroscience methods

authors： Yamaoka Y,Abe C,Morita H

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Microscope chambers that accept glass coverslips with cultured cells are often used to monitor intracellular Ca2+ concentration ([Ca2+]i) during cell superfusion. Unfortunately, the experimental maneuvers associated with the coverslip installation in these chambers (medium removal and re-application) trigger...

journal_title：Journal of neuroscience methods

authors： Kiedrowski L,Feinerman A

更新日期：2018-01-15 00:00:00

abstract：BACKGROUND:Dielectric damage occurring in vivo to neural electrodes, leading to conductive material exposure and impedance reduction over time, limits the functional lifetime and clinical viability of neuroprosthetics. We used silicon micromachined Utah Electrode Arrays (UEAs) with iridium oxide (IrOx) tip metallizatio...

journal_title：Journal of neuroscience methods

authors： Caldwell R,Sharma R,Takmakov P,Street MG,Solzbacher F,Tathireddy P,Rieth L

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Fluorescence membrane markers are efficient tools for visualizing the dynamics of membrane recycling processes in living cells. The outer hair cell (OHC) - a bipolar epithelial cell in the cochlea - possesses endocytic activity at both its apical and basal poles. The best visual overview of transcytosis in t...

journal_title：Journal of neuroscience methods

authors： Harasztosi C,Klenske E,Badum S,Harasztosi E,Gummer AW

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Planarians, like rodents, instinctively spend more time in dark versus light environments when given a choice. This behavioral phenomenon is called negative phototaxis, which may reflect defensive responding related to an anxiety-like phenotype. NEW METHOD:We propose a planarian light/dark test, designated ...

journal_title：Journal of neuroscience methods

authors： Zewde AM,Yu F,Nayak S,Tallarida C,Reitz AB,Kirby LG,Rawls SM

更新日期：2018-01-01 00:00:00